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Cholestatic hepatitis after diagnostic ajmaline challenge

Journal Volume 80 - 2017
Issue Fasc.3 - Case reports
Author(s) C. Hamoir, H. Dano, M. Komuta, P. Druez, S. Negrin Dastis
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(1) Service de Gastroentérologie, Grand Hopital de Charleroi, Charleroi, Belgium ; (2) Service d'Anatomopathologie, Cliniques Universitaires Saint Luc, Brussels, Belgium.

We report a cholestatic hepatitis in an elderly woman after ajmaline challenge during electrophysiological testing for Brugada syndrome. No other medication was reported in the previous 6 months of the onset of jaundice. Liver biopsy showed a choles- tatic hepatitis with mild biliary damage. Liver enzymes normalized within 2 weeks as well as jaundice. To the best of our knowledge this is the second case of histologically proved cholestatic hepatitis induced by intravenous ajmaline testing. (Acta gastroenterol. belg., 2017, 80, 425-426).

© Acta Gastro-Enterologica Belgica.
PMID 29560676